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KMID : 1024220130280010012
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Environmental Health and Toxicology : EHT
2013 Volume.28 No. 1 p.12 ~ p.12
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No Association between Tumor Necrosis Factor-alpha Gene Polymorphisms and Lung Cancer Risk
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:Kim Jin-Hee
:Hong Yun-Chul
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Abstract
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Objectives: The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-α) for lung cancer development was evaluated.
Methods: Genotypes of the TNF-α polymorphisms, -1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, were determined in 616 lung cancer cases and 616 lung cancer-free controls.
Results: After adjusting for body mass index and smoking, each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p>0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C>T, -487A>G, -417A>G, IVS1+123G>A, and IVS3+51A>G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p>0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p>0.05).
Conclusions: This study found no association between common variants of the TNF-α gene and lung cancer risk.
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KEYWORD
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Lung cancer risk, Polymorphism, Tumor necrosis factor-alpha
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